The Primary
Cancer is caused by a number of changes in the genes in our body that control cell growth or regulate the detection and repair of DNA damage. Often there is more than one gene involved in cancer development. The mutations that can lead to cancer may be inherited or acquired.
The point of origin in the body, where the genes have caused cells to grow uncontrollably and form a tumour, is known as the Primary Site. In most cases the primary site is obvious and quickly diagnosed.
Strictly speaking one might say that CUP exists from the point someone knows they have cancer until they know for certain the site of the primary. But our concern is with CUP where there has been tumour spread but it is impossible to tell from initial tests (X-rays, blood tests, scans etc.) where the cancer began.


